The invention provides an anaesthetic mask disinfection device. The outer side walls of an inner cylinder and an outer cylinder are provided with a plurality of guiding holes; the middle part of the inner cavity of the inner cylinder is provided with an anaesthetic mask fixing device, and the bottom is fixedly connected with the bottom of a disinfection cylinder; an outer cylinder slide guide frame is vertically arranged in a set position on the side wall of the outer cylinder; the outer cylinder is sleeved outside the inner cylinder, the bottom is fixedly connected with the bottom of the disinfection cylinder, the side wall is movably connected with the outer cylinder slide guide frame, and the upper part is connected with the driving end of an outer cylinder slide driving device; and the output end of a disinfection controller is connected with the control end of the outer cylinder slide driving device to drive the outer cylinder to vertically reciprocate along the outer cylinder slide guide frame according to a set driving speed. The anaesthetic mask disinfection device solves the problems of low disinfection efficiency, poor disinfection effect and high loss possibility in the existing anaesthetic mask disinfection process. Thus, the secondary pollution in an anaesthetic mask repetitive operation process is reduced, the disinfection efficiency is improved, and a favorable elimination effect is ensured.