The invention provides a preparation method of a taxane compound and an intermediate of the taxane compound. The preparation method of a TPI-287 intermediate A starts with a starting step of a raw material 10-deacetylbaccatin III (also named as 10-DAB), and comprises the following steps: firstly, protecting C-7 site hydroxyl of the 10-DAB and carrying out selective oxidization reaction to obtain the TPI-287 intermediate A. A good foundation is provided for subsequent steps and the problems that the yield of the intermediate is low, the intermediate is difficult to purify and the like are solved; the preparation method provided by the invention has relatively simple steps and controllable reaction conditions; reaction raw materials are cheap and easy to obtain; the preparation method has relatively high yield and is suitable for large-scale production. The TPI-287 intermediate A prepared by the preparation method is used as a key intermediate of TPI-287 and can be used for preparing a potential anti-cancer drug TPI-287 with anti-cancer activity.