The invention relates to the field of a medicine for preventing and treating osteoporosis. The invention provides a pyrazole heterocyclic compound or pharmaceutically acceptable salt of the compound. An in-vivo test finds out that the pyrazole heterocyclic compound can be used for inhibiting bone turnover rate enhancement and bone destruction, which are caused by ovariectomy; meanwhile, the concentration of blood calcium can be improved and deposition of bones is facilitated, so that the pyrazole heterocyclic compound has remarkable effects of preventing and treating the osteoporosis.