The invention provides a preparation method and device for preparing microspheres through gas. The preparation method comprises the steps of pushing protection gas into a preparation device, dropping solution into the preparation device and curing the added solution into spheres in solution in a receiving device to obtain target microspheres. The invention creatively provides the preparation method for preparing microspheres through gas, especially multi-surface incongruous microspheres; experiment equipment is simple and easy to assemble; utilized materials are all degradable materials with no pollution; the utilized method is simple and green and achieves quick preparation and uniform particle size; based on the advantages, all incongruous microspheres prepared through the method has wider potential application.