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CN106929003A 一种多功能近红外荧光探针及其制备方法和应用 有权

一种多功能近红外荧光探针及其制备方法和应用
Abstract:
本发明提供了一种多功能近红外荧光探针，化学结构式如式(Ⅰ)所示：式(Ⅰ)中，X1为‑S‑或‑Se‑，R'为C1‑12的亚烷基，X2为‑C(CH3)2‑、‑O‑、‑S‑或‑Se‑，R1和R2分别独立地选自H原子、C1‑18烷基或如SO3R9所示的基团，其中，R9为C1‑18烷基或苄基，R3和R4分别独立地选自C1‑18烷基或苄基，R5、R6、R7和R8分别独立地选自C1‑18烷基或含有F、Cl、Br、I、O和S中的至少一种的C1‑18烷基，Y1和Y2分别独立地选自F、Cl、Br或I。所述多功能近红外荧光探针能同时实现对pH值和硫醇的检测，且为双响应的比率型近红外荧光探针，还能用于肿瘤的光动力治疗。本发明还提供了该探针的制备方法及应用。
Abstract(English):

The invention provides a multifunctional near infrared fluorescent probe. The chemical formula of the multifunctional near infrared fluorescent probe is as shown in formula (I), wherein X<1> is -S- or -Se-, R' is C1-12 alkylene, X<2> is -C(CH3)2-, -O- or -Se-, each of R1 and R2 is independently selected from H atoms, C1-18 alkyl or groups as shown in SO3R9, R9 is C1-18 alkyl or benzyl, each R3 and R4 is independently selected from C1-18 alkyl or benzyl, each of R5, R6, R7 and R8 is independently selected from C1-18 alkyl or C1-18 alkyl containing at least one of F, Cl, Br, I, O and S, and each of Y1 and Y2 is independently selected from F, Cl, Br or I. The multifunctional near infrared fluorescent probe can simultaneously detect pH and mercaptan, is a double-response ratio type near infrared fluorescent probe and can be used for the photodynamic therapy of tumors. The invention further provides a preparation method and application of the probe.

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