The invention provides an AC micro-grid operation control method and device, and belongs to the technical field of a power grid. The method comprises the following steps: based on a regulation and control model of each distributed micro source in an AC micro-grid, calculating an output voltage and reference frequency of each distributed micro source; according to the output voltage and an reference frequency value of each distributed micro source, calculating a sine voltage reference value of each distributed micro source; and, according to the sine voltage reference value of each distributed micro source, regulating each cascade inverter. The output voltage and the reference frequency of each distributed micro source are calculated based on the regulation and control model of each distributed micro source in the AC micro-grid. The cascade inverters are regulated according to the output voltage and the reference frequency value of each distributed micro source. Regulation and control models can be obtained according to local information, and the cascade inverters are regulated according to the regulation and control models, so non-communication economic operation control for the AC micro-grid based on the cascade inverters can be achieved.