The invention relates to an N-substituted benzenesulfonyl-azaindole oxy-benzamide compound, a crystal form, pharmaceutically acceptable salts, aquo-complex, solvates or prodrugs thereof, and a preparation and pharmaceutical application thereof. The structural formula of the compound is of formula (I) as shown in the specification. Tests show that the compound has relatively high inhibition activity upon antiapoptosis members of a Bcl-2 protein family and HDAC (Histone Deacetylase), has combination selectivity, and also has wide-spectrum antineoplastic activity upon human neoplastic hematologic disorder (myeloma and leukemia) and solid tumors (ovarian cancer, breast cancer, melanin and lung cancer). The compound has potential application of preparing treatment medicines for diseases related to Bcl-2 or HDAC activity, preparing anti-tumor medicines, and preparing synergists and other anti-tumor medicines or being used together with radiotherapy to treat tumors.