An ophthalmic surgical device (10) includes a housing (12) having a distal end (14) and a proximal end (16). A cannula (18) is attached to the housing distal end (14) and has a distal tip (20) with at least one port (22) in communication with a lumen (19) extending through the cannula (18) and in communication with an aspiration path (24) in the housing (12). A vibration source (26) is held within the housing (12) for vibrating the distal tip (20) for assisting in vitreous and other tissue removal. An aspiration source (152) is connected to the aspiration path (24) for applying a negative pressure to the lumen (19) and the at least one port (22) for removing fluids and the vitreous and other tissue from the eye.