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Invention Grant
CN107001348B 2-吗啉-4,6-二取代的嘧啶衍生物、其制法与医药上的用途 有权

2-吗啉-4,6-二取代的嘧啶衍生物、其制法与医药上的用途
Abstract:
一种如下式(I)所示的2‑吗啉‑4,6‑二取代的嘧啶衍生物、其药学上可接受的盐、溶剂化物、立体异构体或其前药，其药物组合物及其应用，其中各基团定义如说明书中所示。所述化合物具有PI3K激酶抑制活性，对ΡΙK3CA突变型乳腺癌细胞株T47D和MCF‑7具有较高的抑制性和低细胞毒性。
Abstract(English):

Disclosed is a 2-morpholin-4,6-disubstituted pyrimidine derivative as shown in formula (I) below, and a pharmaceutically acceptable salt, solvate, stereoisomer or prodrug thereof, and a pharmaceutical composition thereof and a use thereof, wherein the definition of each group is as shown in the description. The compound has a PI3K kinase inhibition activity, and has a relatively high inhibitive ability and a low cytotoxicity against PIK3CA mutant breast cancer cell strains T47D and MCF-7.

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