The embodiment of the invention provides a method for determining a target protection road section and a server. The method comprises a step of determining multiple candidate road sections l to a designated position outside an urban area and inside the urban area, a step of receiving running vehicle position information outside and inside the urban area, a step of obtaining a road condition state parameter state and traffic parameter Gamma C according to each candidate road section l and the running vehicle position information, and forming a road network basic state parameter group tau=, and a step of determining the target protection road section according to the basic state parameter group, an observation beginning time Tbgan and an observation ending time Tend. The server executes the above method. The embodiment of the invention provides the method for determining the target protection road section and the server, and a traffic road section with the need of a key guarantee can be accurately determined.