The invention discloses a multi-channel echo cancellation circuit and method, and an intelligent device. The circuit comprises signal extraction circuits, wherein one of the ends of the signal extraction circuits is connected with an audio channel of a corresponding loudspeaker to extract a part of audio signals from the audio channel of the corresponding loudspeaker to serve as echo cancellation reference signals; the other ends of the signal extraction circuit are connected with isolation circuits; the isolation circuits are connected with one another to form a noise channel, a path of noise signals is formed by the echo cancellation reference signals extracted from the signal extraction circuits and is output to a processor, and the processor subtracts the noise signals from the sound signal collected by a microphone according to the input noise signals and the sound signal collected by the microphone to obtain signals after noise reduction. The multi-channel echo cancellation circuit and method support multi-channel echo cancellation, thereby improving the echo cancellation performance and improving the output voice quality of the multi-channel audio. The intelligent device comprises the multi-channel echo cancellation circuit. The user experience is better.