Provided is a method for populating printed circuit boards, which includes the steps of acquiring jobs, in each case relating to populating printed circuit boards of a printed circuit board type on the pick-and-place line, and associated probabilities by a job is to be executed in each case, assigning printed circuit board types of the jobs to set-up families, determining for each set-up family the characteristic number which comprises the sum of probabilities of those jobs, the printed circuit board types of which are comprised by the set-up family, optimizing the assignment in such a way that the characteristic numbers of different set-up families are as different as possible, providing a set-up from one of the determined set-up families on the pick-and-place line, and populating printed circuit boards on the pick-and place line.