The invention discloses a full-automatic granular preparation dispensing device. The device comprises a shell, a feed inlet is formed in the upper end of the shell, the shell is internally provided with a medicinal material processing chamber and a base, the medicinal material processing chamber is located on the base, a discharging port is formed in the bottom of the medicinal material processing chamber, and an electromagnetic valve is arranged on the discharging port; a sliding groove is formed in the side wall of the bottom of the medicinal material processing chamber, and an electric telescopic rod is arranged below the medicinal material processing chamber; the telescopic end of the electric telescopic rod is downwards arranged, the electric telescopic rod is connected with the sliding groove in a sliding mode through a sliding block, and a conveying device is fixedly arranged on the upper side of the base; two cavities are symmetrically formed in the base, and ozone disinfection devices are fixedly arranged on the side walls of the cavities. According to the device, the whole process is fully automatic, the situation that people participate in the dispensing process and accordingly medicine is contaminated due to the influence of external factors is avoided, and full automation can improve the working efficiency of the device.