The invention discloses an anti-radiation interlayer pipeline, and belongs to the technical fields of radiation protection and pipeline conveying. The anti-radiation interlayer pipeline comprises a first diameter pipeline and a second diameter pipeline which are different in diameter, wherein the second diameter pipeline sleeves the first diameter pipeline to form an interlayer pipeline; a center hole is formed in the first diameter pipeline; an interlayer is formed between the first diameter pipeline and the second diameter pipeline; the interlayer is filled with slurry which is cured to form a polymer intermediate layer; the slurry is prepared from a pre-polymer, shielding radioactive functional powder and inorganic modified powder; the mass ratio of the total mass of the shielding radioactive functional powder and the inorganic modified powder to the mass of the pre-polymer is (0.5 to 4.0) : 1.0. In a process of preparing the slurry, the shielding radioactive functional powder and the inorganic modified powder are added; a preparation method has the advantages of simple process, easy popularization and application and very high practicability.