There is provided an image pickup device and an image pickup method for estimating the depth of an image having a repetitive pattern with high accuracy. The peripheral cameras are arranged according to base line lengths based on reciprocals of different prime numbers as having a position of a reference camera, to be a reference when images from different viewpoints are imaged, as a reference. The present disclosure is capable of being applied to a light field camera and the like, for example, which includes the reference camera and the plurality of peripheral cameras, generates a parallax image from the images of plural viewpoints, and generates a refocus image by using the images from the plural viewpoints and the parallax image.