A supercharged internal combustion engine has cylinder groups with plural cylinders and plural exhaust gas turbochargers. Exhaust gas can be fed to at least one first exhaust gas turbocharger from first outlet valves of the cylinders of the first and second cylinder groups via at least one first exhaust manifold. Exhaust gas can be fed to at least one second exhaust gas turbocharger from second outlet valves of cylinders of the first and second cylinder groups via a second exhaust manifold. At low rotational speeds and/or in part load and/or non-steady state operation, exhaust gas can be fed via the first exhaust manifolds that are connected to the first outlet valves per cylinder group to a turbine of the first exhaust gas turbocharger in flows that can be divided in the inflow region of the turbine, while the second exhaust gas turbocharger is inactive.