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Invention Grant
CN107299134B 一种用于诊断PRCC-TFE3易位性肿瘤的PCR引物组合及其应用 有权

一种用于诊断PRCC-TFE3易位性肿瘤的PCR引物组合及其应用
Abstract:
本发明公开了一种用于诊断PRCC‑TFE3易位性肿瘤的PCR引物组合及其应用。一种PRCC‑TFE3融合基因，由PRCC外显子5和TFE3外显子4融合形成。一种检测PRCC‑TFE3易位性肿瘤的PCR引物，为检测本发明所述的PRCC‑TFE3融合基因的PCR引物：SEQ ID NO.1所示的PRCC‑E5‑F和SEQ ID NO.2所示的TFE3‑E4‑R。本发明扩大了原引物组合的检测范围，应用于临床，可提高诊断该类肿瘤的检出率和准确率。
Abstract(English):

The invention discloses a PCR (polymerase chain reaction) primer for diagnosing PRCC-TFE3 heterotopic tumors and an application thereof. A PRCC-TFE3 fusion gene is formed by fusing a PRCC exon 5 and a TFE3 exon 4 together. The PCR primer for detecting the PRCC-TFE3 heterotopic tumors is a PCR primer for detecting the PRCC-TFE3 fusion gene provided by the invention: PRCC-E5-F shown by SEQ ID NO.1 and TFE3-E4-R shown by SEQ ID NO.2. The PCR primer disclosed by the invention extends the detection range of an original primer combination, and can improve the detectable rate and the accuracy rate of diagnosing this type of tumors when applied clinically.

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