The present invention relates to an AMOLED pixel drive circuit. The drive circuit comprises: a first thin film transistor (T1), wherein a top-gate electrode is connected to a first node (G), a bottom-gate electrode is connected to a second node (B), and a source electrode and a drain electrode are respectively connected to a high power supply potential (VDD) and a third node (S); a second thin film transistor (T2), wherein a gate electrode thereof is connected to a scan line (Scan), and a source electrode and a drain electrode thereof are respectively connected to the first node (G) and a first data line (Data1); a third thin film transistor (T3), wherein a gate electrode thereof is connected to the scan line (Scan), and a source electrode and a drain electrode thereof are respectively connected to a detection signal line (Sense) and the third node (S); a fourth thin film transistor (T4), wherein a gate electrode thereof is connected to the scan line (Scan), and a source electrode and a drain electrode thereof are respectively connected to the second node (B) and a second data line (Data2); a first capacitor (C) connected to the second node (B) and the high power supply potential (VDD); a second capacitor (Cst) connected to the first node (G) and the third node (S); and an organic light-emitting diode (D1), wherein an anode thereof is connected to the third node (S). The present invention effectively compensates for the electrical drift of a driving TFT.