The invention discloses a single nucleotide polymorphism site related to HCV infected liver cirrhosis and an application thereof. The technical scheme provided by the invention is the application of a substance for detecting rs12252 polymorphism or genotype in human genome in preparing a product for screening a HCV infected liver cirrhosis patient. The substance for detecting rs12252 polymorphism or genotype and the other substances (such as, the substances for detecting other single nucleotide polymorphisms or genotypes related to the HCV infected liver cirrhosis) are combined for preparing the product for screening the HCV infected liver cirrhosis patient.