The invention relates to the technical field of health care products and particularly relates to a composition and its use in preparation of a product for treating hyperlipidemia. The composition is composed of krill oil, fish oil extract and Plukenetia volubilis Linneo oil. The composition treats hyperlipidemia. Through cooperation of the three components, significant synergism is obtained. Under the same dosage, the composition has hyperlipidemia improvement effects better than a two-component preparation or a single-component preparation and p is less than 0.05. The composition has low arsenic content and satisfies the health product arsenic content standard in the food safety national standard health food.