The invention provides a collagen secretion promotion ultrashort peptide and application thereof, and belongs to the technical field of biomedicine. The ultrashort peptide comprises at least one kind of materials from ultrashort peptides Magin-WH, Tinin-WH and Orin-G-OT, has the capability of promoting the collagen synthesis, and has the characteristics of very strong oxidization resistance, anti-aging performance, small molecular weight, simple structure, very low cell toxicity, no hemolytic activity, simple preparation method and the like. The ultrashort peptideis used for preparing medicine for treating injured skin restoration and regeneration, such as medicine for treating burnt injury, scald injury and skin ulceration, and can replace EGF to be used in the fields of anti-aging and anti-oxidization beatification skin care product new raw materials for skin restoration and skin collagen proliferation simulation and the like. The ultrashort peptide has small molecular weight and simple structure; the used chemical synthesis method has very low cost; the ultrashort peptide has the obvious beneficial characteristics through being compared with EFG with the sale price being nearly 2 million U.S dollars per gram.