The present disclosure provides compositions and dosage forms comprising sinetirucallol, and methods of using such compositions, such as to treat an inflammation associated disease, liver fibrosis, wound healing, and/or an autoimmune disease. In some embodiments, the composition comprises a Spiranthes sinensis extract. In view of the foregoing, there exists a need for improved compounds for treating inflammation, neurodegenerative diseases, and autoimmune disorders. This disclosure provides compounds, compositions, and methods that address this need, and provide other advantages as well.