The invention discloses a setting value determination method and device. The method comprises steps that a configuration parameter of target equipment is acquired; according to the configuration parameter of the target equipment, matching with a setting case of a preset knowledge database is carried out according to preset matching rules to acquire a target setting example, and each setting case of the preset knowledge database at least comprises one piece of protection equipment and a setting value corresponding to the protection equipment; a setting value of the target equipment is acquired through the target setting example. The method is advantaged in that a technical problem of low setting value calculation efficiency caused by multiple equipment models existing in the prior art is solved.