The invention discloses a denitrification method of coke oven smoke. The denitrification method of the coke oven smoke comprises physical adsorption, empty smoke mixing, combustion reaction, smoke-smoke mixing, evaporation mixing, denitrification reaction, water vapor heat transfer and gas-gas heat transfer. The denitrification method of the coke oven smoke comprises the following steps: using coke powder to adsorb impurities of the coke oven smoke to be subjected to denitrification such as tar, making a part of the coke oven smoke mixed with heated air, and carrying out a low-nitrogen combustion reaction with coke oven gas to generate high-temperature smoke, then directly contacting with water vapor atomized ammonia droplets to form a reaction suitable ammonia/smoke mixture, then performing a denitrification reaction to remove most of nitrogen oxides, and making the smoke exchange heat with feed water and air through a heat exchanger successively, wherein the former becomes water vapor after absorbing heat, one part of the water vapor is used as an atomizing medium and the other part is returned to a coking plant, and the latter is mixed with the coke oven smoke after heated, finally purified smoke is discharged to atmosphere. The method adopts low-nitrogen combustion of smoke recirculation and direct injection of ammonia water to realize high-efficiency denitrification of coke oven smoke SCR, and has the advantages of compact system, high efficiency and energy saving and product recycling.