The invention discloses a centralized temperature and humidity intelligent control system which is used for improving the temperature and humidity control efficiency and the temperature and humidity control accuracy of a temperature and humidity independent control air conditioner system and improving the user experience. The temperature and humidity intelligent control system comprises an intelligent cloud platform, a primary central controller, a plurality of secondary central controllers, fresh air control system equipment used for achieving fresh air within a covered area and a plurality of temperature and humidity controllers based on a fresh air control system, wherein the intelligent cloud platform is used for sending a first control instruction to the fresh air control system through the primary central controller and receiving environment temperature and humidity data reported by all the temperature and humidity controllers through the secondary central controllers connected with the temperature and humidity controllers; the primary central controller is used for sending the first control instruction to the fresh air control system equipment connected with the primary central controller after receiving the first control instruction sent by the intelligent cloud platform; and the secondary central controllers are used for sending the environment temperature and humidity data to the intelligent cloud platform after receiving the environment temperature and humidity data sent by the temperature and humidity controllers connected with the secondary central controllers.