The invention discloses an anti-CA (candida albicans) product combining harmine hydrochloride and fluconazole and an application of the product and belongs to the technical field of medicines. The combined antifungal function of fluconazole and harmine hydrochloride on drug-resistant CA are researched with multiple methods. The effective concentration of fluconazole to harmine hydrochloride is 1:32 (mu g/mL, for CA3) or 1:16 (mu g/mL, for CA2) when fluconazole and harmine hydrochloride are combined to be applied, the minimum inhibitory concentration is 8 mu g/mL and 0.25 mu g/mL (for CA3) or 0.5 mu g/mL (for CA4). When harmine hydrochloride and fluconazole are combined, the antibacterial activity of fluconazole for drug-resistant CA can be enhanced, the coordinated antifungal action can be generated, the drug resistance of drug-resistant CA to fluconazole can be reversed, and a research direction is provided for development of new drugs and new application of old drugs.