A driving method for a display panel (10) and a display device, said method comprising: dividing pixels into multiple pixel groups (100, 200, 100', 200'), each of the pixel groups (100, 200, 100', 200') comprising an adjacent first pixel unit (110, 210, 110', 210') and second pixel unit (120, 220, 120', 220'), each of the pixel units (110, 210, 110', 210', 120, 220, 120', 220') comprising a first sub-pixel, a second sub-pixel, and a third sub-pixel arranged in sequence (S100); displaying each image in sequence by using multi-frame images, and dividing the multi-frame images into two groups of a first frame unit and a second frame unit having same frames (S200) acquiring a first voltage signal and a second voltage signal of each of the pixel groups (100, 200, 100', 200') of each frame image (S300); adjusting the first voltage signal and a second voltage signal, such that average signals of the first voltage signals of all the frame images are the same, average signals of the second voltage signals of all the frame images are the same, the first voltage signals of different pixel groups (100, 200, 100', 200') have the same average signal in the multi-frame images, the second voltage signals of different pixel groups (100, 200, 100', 200') have the same average signal in the multi-frame images (S400).