The invention relates to a load-bearing driving assembly for a vehicle sliding plug door. The load-bearing driving assembly for the vehicle sliding plug door comprises a bearing frame, a first linearslide rail arranged on the side wall of the bearing frame, a slide way located on one side of the bearing frame and fixedly arranged, a driving assembly, a sliding plug mechanism arranged on the end portion of the bearing frame and guiding the bearing frame to move front and back relative to the slide way, and a main door carrying frame connected to the first linear slide rail in a sliding mannerso as to drive a door leaf to slide in the axial direction of the first linear slide rail under the effect of the driving assembly, wherein the slide way comprises a straight way and a bent way formedat one end of the straight way; the main door carrying frame is rotationally connected to the driving assembly through a connection device; the main door carrying frame is provided with a guiding wheel is limited in the slide way in a sliding manner; and the guiding wheel can move along the slide way along with the main door carrying frame. According to the load-bearing driving assembly for the vehicle sliding plug door, by means of a driving mechanism, the linear slide rail, a support and the door carrying frame, opening and closing and sliding of the door leaf can be achieved, the structureis simple, the linear slide rail is easy to machine and manufacture compared with a lead screw, abrasion cannot be caused even though a sliding frame slides along the linear guide rail, and safety ishigh.