The invention discloses an anti-slide guide rail. The anti-slide guide rail comprises a guide rail body, a dustproof outer shell, a damping layer, a base, mounting brackets, a rubber plate, a metal plate, a knob, pressure sensors, a controller, an independent power source, reset springs, damping pads and rotating motors. The top end of the guide rail body is fixedly connected with the dustproof outer shell through screws, and the mounting brackets are arranged on left and right sides of the top surface of the dustproof outer shell. Compared with the prior art, the anti-slide guide rail has advantages that the anti-slide guide rail is scientific and reasonable in design, the rotating motors are controlled by the controller to drive bolts to rotate, then the bolts drive the damping pads to move upwards to effectively fix an article sliding to the position, inconvenience caused by sliding in use is avoided, the rubber plate and the metal plate are changed through rotating of the knob so as to adjust friction of the guide rail, and sliding of the article at the position is effectively stabilized.