The invention discloses a loudspeaker adaptation method and device for vehicle-mounted sound equipment, and belongs to the technical field of vehicle-mounted electronic appliances. The method comprises the steps of the vehicle-mounted sound equipment scanning a configuration code of a target vehicle through electric detection equipment, and acquiring the configuration information of a loudspeakerof the target vehicle from the configuration code; determining a target parameter set corresponding to the configuration information of the loudspeaker of the target vehicle from the corresponding relation between the pre-stored configuration information and the parameter set according to the configuration information of the loudspeaker; the vehicle-mounted sound equipment directly determining thetarget parameter set as the configuration parameter of the loudspeaker, and writing the target parameter set into a designated storage space corresponding to the vehicle-mounted sound equipment of the target vehicle, so that the loudspeaker converts an electric signal of the vehicle-mounted sound equipment into a sound signal based on the target parameter set. The adaptation of the loudspeakers of various vehicles can be realized without manual operation, and the efficiency of the adaptive loudspeaker is improved.