The invention relates to the technical field of flanges, in particular to a flange with an anti-skid groove-shaped gasket and a pressure sensor and a manufacturing method. The flange with the anti-skid groove-shaped gasket and the pressure sensor comprises a flange body and a bolt installing hole formed in the flange body; the part, located on the end face of the bolt installing hole, of the flange is integrally provided with an annular gasket; the annular gasket sequentially comprises a non-conductive bottom layer, a metal resistance strain gage layer and a non-conductive anti-skid layer, wherein the bottom layer and the end face of the bolt installing hole are combined, the metal resistance strain gage layer is combined with the bottom layer, the anti-skid layer and the metal resistancestrain gage layer are combined, and the anti-skid face of the anti-skid layer is provided with an anti-skid groove. The bolt hole of the flange is integrally provided with the gasket internally provided with a metal resistance strain gage, the pressure of a bolt is transmitted to the metal resistance strain gage, and the metal resistance strain gage is connected to a monitoring control system so that dynamic monitoring of pre-tightening force of the bolt can be achieved.