The invention relates to the field of the synthesis of organic compounds, in particular to a synthesis method for anti-cancer compound CX1409. The anti-cancer compound CX1409 is characterized in that10-deacetylbaccatine III is taken as a starting material, 7-hydroxy is protected by triethylchloro-silicane (TESCl), then, the 10-deacetylbaccatine III is connected with a docetaxel side chain, a protecting group is removed from the obtained compound by methanoic acid, and finally, the compound reacts with Boc anhydride to obtain target compound CX1409. A synthesis route provided by the inventionhas the advantages of convenience in operation, moderate reaction condition, high yield and wide application prospect and is suitable for industrial production, and column chromatography purificationcan be avoided.