The invention relates to a double-main-shaft double-tool-tower machine tool. The double-main-shaft double-tool-tower machine tool comprises a left main shaft, a right main shaft, a left tool tower, aright tool tower and a protection assembly, wherein a machining area of a machine tool body is isolated from an equipment operation area through the protection assembly. The protection assembly comprises a left side middle partition plate, a right side middle partition plate, a guide rail protection plate, a left tool tower protection housing, a right tool tower protection housing and a right mainshaft protection housing. The left side middle partition plate is vertically arranged at the left side of the machining area and fixed to the left main shaft of the machine tool body. The right sidemiddle partition plate is fixed to the right side of the machining area in the vertical direction and located above the right main shaft protection housing. The guide rail protection plate is arrangedat the rear sides of the left side middle partition plate and the right side middle partition plate and connected with the left tool tower protection housing and the right tool tower protection housing. By means of the double-main-shaft double-tool-tower machine tool, iron scraps and cutting fluid generated in the machining area of the machine tool body are prevented from splattering to the electric equipment operation area; safety of electric equipment is improved; and in addition, maintenance cost is lowered.