The invention discloses an insecticide composition with cartap and imidacloprid and an application of the insecticide composition. The insecticide composition with cartap and imidacloprid comprises main effective components, namely the cartap and the imidacloprid, wherein the mass ratio of the cartap to the imidacloprid is (30:1)-(1:30). The insecticide composition disclosed by the invention can be applied to prevention and treatment on root-knot nematode in vegetables, peanuts, sweet potatoes, forests, flowers, nursery gardens, rice or wheat, and snout moth's larvae on rice.