The invention provides an application of mononucleotide polymorphic sites in risk assessment of traumatosepsis, and a traumatosepsis risk assessment system exploited based on the mononucleotide polymorphic sites. The mononucleotide polymorphic sites comprise a rs5743551 carried A allele, a rs4755453 carried C allele, a rs1065489 carried T allele, a rs2071746 carried T allele, a rs1799983 carried Tallele, a rs2297518 carried G allele, a rs740598 carried G allele, and a rs7851696 carried T allele. The mononucleotide polymorphic sites or the traumatosepsis risk assessment system can better identify the high-risk population of traumatosepsis, heredity risk factor scores of traumatosepsis of to-be-measured individual can be calculated by clinician, an individuation genotype detection report ofa to-be-measured object is completed, and the application has high reference value for predicting or preventing traumatosepsis and exploiting a novel drug for treating traumatosepsis.