The invention discloses a large-scale structure multiagent health monitoring system. The system comprises a PZT sensing main body, a fiber Bragg grating sensor main body, a strain sensing main body and a piezoelectric driving main body which are arranged on a large-scale structure body. A part of the PZT sensing main body is connected to corresponding bolt loosening signal processing main bodies.The rest of the PZT sensing main body is connected to corresponding impact load signal processing main bodies. There are a plurality of bolt loosening signal processing main bodies. The plurality of bolt loosening signal processing main bodies are connected to a bolt loosening assessment main body. There are a plurality of impact load signal processing main bodies. The plurality of impact load signal processing main bodies are connected to an impact load assessment main body. The fiber Bragg grating sensor main body is connected to a corresponding static state load signal processing main body.In the invention, a lot of redundancy information in the system can be removed, and complementary information among different main bodies can be reasonably used so that complete structure state information can be finally acquired.