Provided are a compensation method, apparatus and circuit for a display panel, a display panel and a display apparatus, which relate to the technical field of display. The display panel comprises multiple pixel circuits, each of the pixel circuits comprising a drive transistor. The compensation method comprises: obtaining a first compensation grayscale value GL1 and second compensation grayscale value GL2 of a pixel circuit to be compensated; obtaining first compensated luminance L1, a first gate-source voltage Vgs1 of a drive transistor, second compensated luminance L2 and a second gate-source voltage Vgs2 of the drive transistor, wherein L1 and Vgs1 correspond to GL1, and L2 and Vgs2 correspond to GL2; obtaining theoretical luminance L corresponding to an input grayscale value GL; by means of the theoretical luminance L, the first compensated luminance L1, the first gate-source voltage Vgs1, the second compensated luminance L2 and the second gate-source voltage Vgs2, obtaining a compensation gate-source voltage V'gs by calculation; and according to the compensation gate-source voltage V'gs, obtaining an output compensation grayscale value GL'. The present disclosure realizes real-time compensation for the light-emitting luminance of a pixel.