The invention belongs to the technical field of titanium alloy hot working forming and particularly relates to a single fire rolling method of a TC4 titanium alloy moderate-thickness plate. For the problems that the multi-fire-time rolling technology generally needs to be adopted for preparing and obtaining a TC4 titanium alloy with an excellent structure property, and forming performance of an alloy rolled in a single fire manner is poor, the single fire rolling method of the TC4 titanium alloy moderate-thickness plate comprises the following steps that a, a TC4 titanium alloy plate blank isheated; b, after soaking is completed, the soaking temperature is increased to 1000 DEG C to 1020 DEG C, the temperature continues to be kept for 30-60 min, and then the plate blank is discharged froma furnace and rolled; c, before rolling is carried out, roller way cooling water and phosphorus removal water are turned off, the beginning rolling temperature is larger than or equal to 950 DEG C, and the final rolling temperature is larger than 800 DEG C; and d, the rolled plate blank is subjected to annealing heat treatment, then the plate blank is discharged from the furnace and cooled in air, and the TC4 titanium alloy is obtained. According to the method, structure uniformity of the rolled TC4 titanium alloy moderate-thickness plate is good, the surface quality is good, and the requirement of the national standard can be met. The rolling technology is simplified, the rolling efficiency is improved, and the production cost is reduced remarkably.