The invention relates to the field of automatic machining equipment, in particular to a twisting mechanism of metal wire twisting machining equipment. The twisting mechanism comprises a supporting wheel, a driving wheel, a motor, a lifting driving assembly and a transverse movement driving assembly. The supporting wheel and the motor are fixedly arranged on the lifting driving assembly. The motoris in transmission connection with the driving wheel. The lifting driving assembly is fixed to the transverse movement driving assembly. The transverse movement driving assembly and the lifting driving assembly are used for driving the supporting wheel and the driving wheel to do the ascending, descending and transverse movement motions, wires penetrate the part between the supporting wheel and the driving wheel, and the wires are twisted along with ascending, descending and transverse movement of the supporting wheel and the driving wheel. The twisting mechanism has the beneficial effects ofbeing simple in structure and low in cost, and has the function of driving the wires to move, and the functions are not single any more.