The invention provides a synthesis method of a basic zinc sulfate scale microsphere, and belongs to the technical field of the preparation of inorganic functional materials. The synthesis method comprises the followings steps: dispersing zinc vitriol into ethanol, promoting zinc vitriol to be dispersed in an ethanol medium in a microsphere way through stirring action, and then adding triethylamineinto a system. The basic zinc sulfate scale microsphere is prepared through the reaction of triethylamine and zinc vitriol in a hydrothermal condition. The formed microsphere comprises a plurality ofbasic zinc sulfate scales tangent to the surface of the microsphere, and a gap formed by the scales in different directions is formed inside the microsphere. The synthesis method is simple, good in reproducibility, and mild in synthesis condition. The invention provides a strategy for synthesizing an inorganic functional compound scale microsphere, and the formed basic zinc sulfate scale microsphere is expected to have a wide application prospect because of the unique structure.