The invention relates to a multi-point locking mechanism. At least two lock bodies are linearly connected; every two adjacent lock bodies are connected through connecting rods to realize linkage; anylock body in linear connection is connected with a power end of an electric cylinder through the connecting rods and release mechanisms, or the lock bodies at the end parts are connected with manual unlocking mechanisms through fixed pins; and corresponding lock tongues are arranged at the externals of all the lock bodies. Only one set of driving mechanisms is connected with the multiple lock bodies through the connecting rods to synchronously finish automatic locking of multiple points so as to realize synchronous opening and locking of large mouth cover equipment needing multi-point locking;a manual unlocking mechanism is provided; when automatic locking is failed, manual unlocking can be performed in the equipment; and the locking mechanism is low in cost, high in efficiency and safe and reliable in locking, and reduces the control difficulty of locking switches.