The invention belongs to the field of a biomedical material, and specifically relates to a polylactic-acid-based bone tissue support loading icariin and deferoxamine, and a preparation and applicationof the polylactic-acid-based bone tissue support. Electrospinning technique is adopted to prepare a polylactic acid micrometer fiber support, which is then modified with a polydopamine layer, and finally, polydopamine is used for synergetic fixing of icariin and deferoxamine to the support. Through utilization of polydopamine, the hydrophilic performance, mechanical properties and cell affinity of the support are improved, and through cooperation of icariin and deferoxamine, the ossification performance and hematopoietic performance of the support are greatly improved. Through further adoption of thermally-induced phase separation, a chitosan nanometer fiber net is compounded on the polylactic acid micrometer fiber support, and based on the composite nanometer fiber net, polydopamine, icariin and deferoxamine are used for modification. The mechanical property of the support is obviously improved, which is beneficial for forming vasoganglion. The used materials are cheap, the adopted electrospinning and thermally induced phase separation technology are simple, and the performance of the material is easy to regulate, so that the support is suitable for industrialization.