The embodiment of the application provides an AVAF simulation method and apparatus based on a multi-scale rock physical model. The method comprises: determining a periodic layered plaque saturated medium model of a reservoir stratum and determining an improved rock matrix modulus of a microscopic jet flow model of the reservoir stratum; substituting the improved rock matrix modulus into the periodic layered plaque saturated medium model to obtain a multi-scale rock physical model of the reservoir stratum; determining a reservoir medium parameter value of the reservoir stratum and a seismic wave dispersion parameter value of the multi-scale rock physical model and establishing a layered media model containing a velocity dispersion interlayer; and carrying out frequency-domain seismic forward modeling on the layered media model with the velocity dispersion interlayer to obtain a frequency-dependent seismic response characteristic of the layered medium model with the velocity dispersion interlayer. Therefore, accurate rock elastic characteristics and seismic response characteristics of tight sandstones can be obtained.