The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a prinsepiol sublingual tablet and a preparation method thereof. The prinsepiol sublingual tablet comprises 1-10 parts of prinsepiol cyclodextrin inclusion, 15-20 parts of filling agent, 1-5 parts of polyethylene glycol 400, 1-6 parts of disintegrant, 1-5 parts of corrigent and 0.5-5 parts of lubricant. Application of prinsepiol in preparing medicine compositions with antipyretic, analgesic and anti-inflammatory functions is provided for the first time. It is proved through a mouse hot plate method and rat carrageenin caused foot swelling experiments that prinsepiol has excellent antipyretic and anti-inflammatory functions. The novel preparation of the prinsepiol sublingual tablet is provided for the first time, the formula is reasonable, the dissolution rate, the disintegration degree and stability tests meet the requirements, and the excellent antipyretic and anti-inflammatory effects are obtained; the prinsepiol sublingual tablet is very convenient to use, is taken by a patient sublingually, is high in compliance and can reduce the pressure of conventional tablet taking, andthe sublingual tablet makes people have an psychological effect of enhancing the antipyretic and anti-inflammatory functions.