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CN108218988B 抗PD-1的纳米抗体PD-1/Nb52及其制备方法与应用 有权

抗PD-1的纳米抗体PD-1/Nb52及其制备方法与应用
Abstract:
本发明公开了抗PD‑1的纳米抗体PD‑1/Nb52及其制备方法与应用。本发明所提供的纳米抗体，包含纳米抗体PD‑1/Nb52的抗原决定簇互补区和骨架区；所述纳米抗体PD‑1/Nb52的抗原决定簇互补区由CDR1、CDR2和CDR3组成；通过本发明所公布的纳米抗体PD‑1/Nb52的核苷酸序列及宿主细胞，该纳米抗体PD‑1/Nb52能够在大肠杆菌内高效表达，应用于PD‑1分子检测试剂的研发，制备抑制PD‑1活性以及制备肿瘤抑制剂或肿瘤细胞抑制剂和促进T细胞增殖的药物。
Abstract(English):

Disclosed are an anti-PD-1 nanobody PD-1/Nb52, a preparation method therefor and a use thereof. The nanobody PD-1/Nb52 can be highly expressed in Escherichia coli, and can be used for preparing tumor inhibitors or tumor cell inhibitors, or drugs for inhibiting PD-1 activity or promoting T cell proliferation.

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