The invention discloses a centrifugal disinfection tower for a closed cultivation farm. The centrifugal disinfection tower for the closed cultivation farm comprises a vertical spray tower; the vertical spray tower comprises a tower body base and a tower body, and the tower body is supported on the tower body base; the tower body base is of a horizontal disc-shaped supporting structure; the tower body is of a cavity rotor structure coaxial with the tower body base; the tower body comprises an upper tower main body and a lower tower main body from top to bottom, the lower tower main body is of acylindrical barrel structure, and a rotation motor is coaxially arranged at the bottom of the barrel portion of the lower tower main body; and fan blades are further coaxially arranged in the lower tower main body and located above the rotation motor, and the rotation motor and the fan blades are connected in a driving mode through a first transmission shaft. The centrifugal disinfection tower for the closed cultivation farm is simple in structure, the tower can spray mist automatically in the running process without the need that workers enter the closed cultivation area, and chemical mist can be diffused to the whole cultivation area quickly by means of the tower-type spraying structure.