The invention discloses a medicine bottle spin-drying machine and method. The medicine bottle spin-drying machine comprises a rotating disc, a rotary driving part and two or more tray assemblies. Thetray assemblies are evenly arranged on the rotating disc in the circumferential direction of the rotating disc. The rotary driving part is used for driving the rotating disc to rotate. The tray assemblies are used for arranging a medicine bottle and enabling the medicine bottle to be kept in the state that a bottle opening is close to the rotating center of the rotating disc and a bottle bottom isaway from the rotating center of the rotating disc. According to the medicine bottle spin-drying method, in the spin-drying process, the medicine bottle is kept in the state that the bottle opening is close to the rotating center of the rotating disc and the bottle bottom is away from the rotating center of the rotating disc. The medicine bottle spin-drying machine has the advantages of being simple in structure, stable in operation, good in spin-drying effect and the like. The medicine bottle spin-drying method has the advantages of being thorough in spin drying, good in spin-drying effect and the like.