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Invention Grant
CN108434454B ADAR1在缓解认知功能障碍方面的应用 有权

ADAR1在缓解认知功能障碍方面的应用
Abstract:
本发明公开ADAR1作为干预靶点在缓解认知功能障碍方面的应用，包括ADAR1在缓解认知功能障碍方面的应用；所述应用包括ADAR1作为干预靶点在缓解认知功能障碍方面的应用，具体是在制备治疗认知功能障碍药物方面的应用。所述的应用包括ADAR1诱导剂或ADAR1抑制剂在制备治疗认知功能障碍药物方面的应用。进一步的，所述的ADAR1诱导剂是IFN‑γ，所述的ADAR1抑制剂是EHNA。所述的应用包括使用ADAR1诱导剂或ADAR1抑制剂促使患者脑内ADAR1恢复到人脑内正常水平。本发明对于揭示认知功能障碍类疾病的发病机制，发现针对该类疾病的药物靶点，进行有效防治，具有重要的理论意义和应用价值。
Abstract(English):

The invention discloses application of ADAR1 as an intervention target to an aspect of relieving the cognition impairment, including the application of the ADAR1 to the aspect of relieving cognition impairment. The application comprises the application of the ADAR1 as an intervention target to the aspect of relieving cognition impairment, concretely the application to an aspect of preparing medicine for treating the cognition impairment. The application comprises the application of ADAR1 inducers or ADAR1 inhibitors to the aspect of preparing the medicine for treating the cognition impairment.Further, the ADAR1 inducer is IFN-gamma; the ADAR1 inhibitor is EHNA. The application comprises an operation of promoting the in-brain ADAR1 of a patient to recover to the normal level in the human brain by using the ADAR1 inducers or ADAR1 inhibitors. The application provided by the invention has the important theoretical significance and application values on disclosing the pathogenesis of cognition impairment diseases, discovering the medicine target point aiming at the diseases and performing effective prevention and treatment.

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