The invention relates to a production line for rolling bags with asymmetric bag openings and a production method. The production line mainly comprises a notching device, a direction-changing device, abottom sealing device and a bag rolling device. The rolling bags are cut into rolling bags with non-flat bag openings through the notching device; the opposite folding direction is changed through the direction-changing device, the notch shapes and the direct-changing opposite folding angles are designed precisely, so that the front-layer bag openings and the rear-layer bag openings after direction changing form staggered peak-valley arrangement; then, the bottoms of the bags are subjected to sealing sticking through the bottom sealing device; and finally, the continuous rolling bags are rolled into rolls through the bag rolling devices. When the rolling bags produced through the production line are used, the edges of the bag openings are staggered in the height direction and in the front-rear direction, and thus finger acting points can be rapidly found to open the rolling bags.