The invention provides a thermos bottle liner cleaning device combining omnibearing cleaning with local obstinate stain removal and relates to the field of domestic sanitary fittings. The problems that a liner is difficult to clean and cleaning is not thorough are solved. The thermos bottle liner cleaning device combining omnibearing cleaning with local obstinate stain removal comprises a limit outer cover, the bottom of the limit outer cover is bonded with a bottom ring, the side wall of the bottom ring is bonded with a pushing-against and pressure type fixed plate, an abutted limit mechanismis arranged inside the limit outer cover, and the top of the limit outer cover is bonded with a locating and cleaning mechanism by virtue of a top connecting rod. The thermos bottle liner cleaning device combining omnibearing cleaning with local obstinate stain removal has the advantages that a pointing angle of a cleaning brush at the end part of a steel wire rotating cylinder can be controlledby adjusting the height of a pointing block as well as stretching out and drawing back the steel wire rotating cylinder, and the height of the cleaning brush can be controlled by controlling a liftingdrum to go up and down, so that omnibearing cleaning is realized; meanwhile, the cleaning brush at the end part of the steel wire rotating cylinder can revolve on the axis, so that specific obstinatestain removal is implemented.